Doctor's Corner

Understanding the effects of Photobiomodulation

Photobiomodulation, also known as low level laser therapy (LLLT), cold laser therapy, and laser biostimulation, is a medical technique in which exposure to low-level laser light enhances tissue growth and healing. The technique is also known as phototherapy and laser therapy.

The following information will help you to understand the effects of Photobiomodulation on the tissues of the body.

Physiological affects:

• Stabilization of cellular membrane of damaged cells
• Enhancement of ATP production and synthesis
• Decreased C-Reactive protein Neopterin
• Acceleration of leukocytic activity
• Enhanced lymphocyte response
• Reduction of Interleukin 1 (IL-1)
• Increased prostaglandin synthesis
• Enhanced superoxide dismutase (SOD) levels
• Stimulation of vasodilation
• Increased angiogenesis (new blood vessels)
• Temperature modulation

Decreased Pain and Nociception:

• Ion channel normalization (results in pain reduction)
• Increase in Beta Endorphins (decreased pain response)
• Increased nitric oxide production (helps oxygenation and synapse normalization)
• Decreased Bradykinin levels
• Blocked depolarization of C-fiber afferent nerves
• Normalization of resting action potentials (back to 70 mv range)
• Increase release of acetylcholine (normalization of nerve function)
• *Axonal sprouting and nerve cell regeneration* (assists in improving nerve function and reducing pain)

Tissue healing:

• Increased leukocyte activity (acceleration of tissue repair and decrease of pain)
• Increased macrophage activity (increased phagocytosis)
• Increased neovascularization (new vessel growth and increase oxygenation)
• Increased fibroblast production (speeds tissue repair)
• Keratinocyte proliferation (Decreased skin healing time and early ephitheliazation)
• Increased tensile strength (helps prevent re-injury)

Normal cells and tissues are not affected!